background:
Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. The axonemal dyneins, found in cilia and flagella, are components of the outer and inner dynein arms attached to the peripheral microtubule doublets. DNAH10 is an inner arm dynein heavy chain (Maiti et al., 2000 [PubMed 11175280]).[supplied by OMIM, Mar 2008]
Function:
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). Probable inner arm dynein heavy chain.
Subunit:
Consists of at least two heavy chains and a number of intermediate and light chains.
Subcellular Location:
Cytoplasm. cytoskeleton. cilium axoneme.
Tissue Specificity:
Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed in brain but not in adult heart.
Similarity:
Belongs to the dynein heavy chain family.
Contains 5 TPR repeats.
Database links:
Entrez Gene: 196385 Human
Omim: 605884 Human
SwissProt: Q8IVF4 Human
Unigene: 622654 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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