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Rabbit Anti-Osteocalcin/FITC Conjugated antibody
background:
Osteocalcin belongs to the osteocalcin/matrix Gla protein family and constitutes 1 to 2% of the total bone protein. It is a 49 amino acid single chain vitamin K dependent protein, made by osteoblasts, and is a major component of the noncollagenous bone matrix. Post translational modification by a vitamin K dependent carboxylase produces three gamma carboxyglutamic acid residues at positions 17, 21 and 24, giving it a high affinity for calcium. It also binds strongly to apatite.
Function:
Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.
Subcellular Location:
Secreted.
Post-translational modifications:
Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
Similarity:
Belongs to the osteocalcin/matrix Gla protein family.
Contains 1 Gla (gamma-carboxy-glutamate) domain.
Database links:
Entrez Gene: 281646 Cow
Entrez Gene: 632 Human
Entrez Gene: 397530 Pig
Entrez Gene: 25295 Rat
Omim: 112260 Human
SwissProt: P02820 Cow
SwissProt: P02818 Human
SwissProt: Q8HYY9 Pig
SwissProt: P04128 Rat
Unigene: 654541 Human
Unigene: 9722 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
骨钙素又称骨γ-羧谷氨酸包含蛋白
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