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Rabbit Anti-ACCN1/FITC Conjugated antibody
background:
Degenerin/epithelial sodium channel (DEG/ENaC) superfamily members are amiloride-sensitive sodium channels that contain intracellular N- and SLCtermini, 2 two hydrophobic transmembrane regions and a cysteine-containing extracellular loop. Acid sensing ion channel ASIC1, also designated ACCN2, BNAC2 and ASIC1a, is present in brain as a 4.3-kb transcript with localization to rat dorsal root ganglia. In situ hybridization of rat brain suggests that ASIC1 is most abundant in the main olfactory bulb, cerebral cortex, hippocampal formation, habenula, basolateral amygdaloid nuclei and cerebellum. ASIC1 and H+-gated currents may contribute to the development of fear and anxiety. ASIC2, also designated amiloride-sensitive cation channel 1, neuronal (ACCN1), mammalian degenerin, BNAC1 (MDEG) and brain Na+ channel 1, mediates the normal detection of light touch. ASIC2 mRNA is abundant in brain, specifically in neurons. ASIC2 is expressed as 2.7- and 3.7-kb transcripts in brain and spinal cord tissues. ASIC3, also designated ASIC3, SLNAC1 and TNaC1, mediates detection of lasting pH changes and is involved in modulating moderate- to high-intensity pain sensation. ASIC4, also designated ACCN4 and BNAC4, is abundant in pituitary gland and is also present in the inner ear.
Function:
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.
Subcellular Location:
Cell membrane. Localized at the plasma membrane of neurons, in the soma and punctated peripheral processes.
Tissue Specificity:
Brain and spinal cord. Isoform 1 is also detected in testis, liver, colon and ovary.
Similarity:
Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ACCN1 subfamily.
Database links:
Entrez Gene: 40 Human
Entrez Gene: 11418 Mouse
Entrez Gene: 25364 Rat
Omim: 601784 Human
SwissProt: Q16515 Human
SwissProt: Q925H0 Mouse
SwissProt: Q62962 Rat
Unigene: 368417 Human
Unigene: 234998 Mouse
Unigene: 37523 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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