background:
The regeneration (REG) family consists of secretory proteins involved in liver, pancreatic, gastric and intestinal cell proliferation or differentiation. Members of the REG family are divided into four subclasses, designated types I, II, III and IV. They have been implicated in the regulation of cell growth, tumorigenesis and the progression of cancer. Specifically, increased expression of Reg III Alpha results in pancreatic inflammation and liver carcinogenesis. Reg III Alpha, also de-signated pancreatitis-associated protein, localizes to the apical region of pancreatic acinar cells and is similar to the SLCtype lectin superfamily. The Reg III Alpha protein is mainly expressed in the intestine, with lower expression detected in healthy pancreas. It is also detected in pancreatic juice as a result of pancreatic inflammation.
Function:
Might be a stress protein involved in the control of bacterial proliferation.
Subcellular Location:
Secreted. Found in the apical region of pancreatic acinar cells.
Tissue Specificity:
Constitutively expressed in the small intestine, moderately in colon and at an extremely low level in healthy pancreas.
DISEASE:
Note=Overexpressed during the acute phase of pancreatitis.
Similarity:
Contains 1 SLCtype lectin domain.
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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