background:
Cystatin A and cystatin B (also designated PME, CST6, STFB, CPI-B, stefin B and liver thiol proteinase inhibitor) are thiol protease inhibitors that form complexes with papain and the cathepsins B, H, and L. Cystatin A, a cytoplasmic protein, is one of the precursor proteins of the cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Cystatin B protects against intracellular proteases leaking out of lysosomes and is primarily expressed in heart, liver and kidney.
Function:
This is an intracellular thiol proteinase inhibitor.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Expressed in the skin throughout the epidermis.
Similarity:
Belongs to the cystatin family.
Database links:
Entrez Gene: 1475 Human
Entrez Gene: 209294 Mouse
Omim: 18920 Human
SwissProt: P01040 Human
SwissProt: P56567 Mouse
Unigene: 518198 Human
Unigene: 300592 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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