background:
Pirh2 has p53-induced ubiquitin-protein ligase activity, promoting p53 degradation. The protein physically interacts with p53 and the resulting degradation of p53 renders Pirh2 an oncogenic protein as the loss of p53 function contributes to malignant tumor development. The gene encoding for the protein maps to chromosome 4q21.1 and transcription of this gene is regulated by p53. Pirh2 expression decreases the level of p53 and a decrease of endogenous Pirh2 expression ups p53 levels. Pirh2 is therefore considered, together with MDM2, to be acting as a negative regulator of p53 function.
Function:
Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Increases AR transcription factor activity (By similarity). Contributes to the regulation of CDKN1B and p53/TP53 levels, and thereby contributes to the regulation of the cell cycle progression.
Subunit:
Monomer and homodimer. Interacts with AR, p53/TP53, MDM2, HDAC1, KAT5, PLAG1, PLAGL2, CDKN1B, COPE, UBE2D2 and GORAB/NTKLBP1 (By similarity).
Subcellular Location:
Nucleus (By similarity). Nucleus speckle (By similarity). Cytoplasm (By similarity).
Tissue Specificity:
Detected in testis, liver, kidney and heart.
Post-translational modifications:
Subject to ubiquitination and proteasomal degradation (By similarity).
Similarity:
Contains 1 CHY-type zinc finger.
Contains 1 CTCHY-type zinc finger.
Contains 1 RING-type zinc finger.
Database links:
Entrez Gene: 771726 Chicken
Entrez Gene: 540733 Cow
Entrez Gene: 25898 Human
Entrez Gene: 13698 Mouse
Entrez Gene: 289508 Rat
Omim: 607136 Human
SwissProt: Q96PM5 Human
SwissProt: Q9CR50 Mouse
Unigene: 48297 Human
Unigene: 159453 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Pirh2通过负反馈调控p53的转录激活和细胞生长抑制功能；
Pirh2蛋白是一个新发现的泛素蛋白连接酶，受到p53的诱导调控表达，可促进p53蛋白的泛素化降解。目前多用于肺癌的研究。
|
|
