background:
Low-density lipoprotein (LDL) is the carrier protein for cholesterol in the blood. LDL binds to its receptor on the capillary walls and thereby mediates the uptake and clearence of cholesterol from the circulation. In atherosclerotic lesions oxidatively modified LDL is found and oxidized LDL is specifically recognized and ingested by macrophages via scavenger receptor A and CD36. Oxidized LDL may be a marker of atherosclerosis but the precise changes in oxidized LDL are not well described. Low-density lipoprotein oxidised with Cu2SO4.
Subcellular Location:
Secreted.
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
氧化低密度脂蛋白是低密度脂蛋白(low density lipoprotein,LDL)经氧化修饰后形成的,经研究认为:OXLDL的增高与动脉粥样硬化性心血管病(Arteriosclerosis cardiovascular disease,ASCVD)的发生有密切关系。
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