background:
Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles and other excitable cells. The KV gene family encodes more than 30 proteins that comprise the subunits of the K+ channels, and they vary in their gating and permeation properties, subcellular distribution and expression patterns. Functional KV channels assemble as tetramers consisting of pore-forming å subunits (KV), which include the KV1, KV2, KV3 and KV4 proteins, and accessory or KSLVsubunits that modify the gating properties of the coexpressed KV subunits. KV∫, also known as KCNAB1 (potassium voltage-gated channel, shaker-related subfamily, beta member 1), is a 419 amino acid accessory K+ channel protein that exists as three alternatively spliced isoforms and regulates the activity of the pore-forming å subunit. It is expressed in brain, with highest levels detected in caudate nucleus, hippocampus and thalamus.
Function:
Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. All three isoforms alter the functional properties of Kv1.4 and Kv1.5. Isoform KvB1.2 has no effect on Kv1.1, Kv1.2 or Kv2.1.
Subunit:
Forms heteromultimeric complex with alpha subunits. Interacts with SQSTM1 (By similarity). Part of a complex containing KCNA1, KCNA4 and LGI1 (By similarity).
Subcellular Location:
Cytoplasm.
Tissue Specificity:
In brain, expression is most prominent in caudate nucleus, hippocampus and thalamus. Significant expression also detected in amygdala and subthalamic nucleus. Also expressed in both healthy and cardiomyopathic heart. Up to four times more abundant in left ventricle than left atrium.
Similarity:
Belongs to the shaker potassium channel beta subunit family.
Database links:
Entrez Gene: 395730 Chicken
Entrez Gene: 526133 Cow
Entrez Gene: 7881 Human
Entrez Gene: 16497 Mouse
Entrez Gene: 100125830 Pig
Entrez Gene: 29737 Rat
GenBank: NP_751891 Human
Omim: 601141 Human
SwissProt: Q9PWR1 Chicken
SwissProt: Q4PJK1 Cow
SwissProt: Q14722 Human
SwissProt: P63143 Mouse
SwissProt: P63144 Rat
Unigene: 654519 Human
Unigene: 703187 Human
Unigene: 311282 Mouse
Unigene: 6490 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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