background:
Orai2 is a 254 amino acid multi-pass membrane protein that belongs to the orai family of proteins. Localizing to the plasma membrane, Orai2 plays an important role in store-operated calcium (SOC) entry, a process involving Ca2+ influx and replenishment of Ca2+ stores formerly emptied through the action of inositol 1,4,5-trisphosphate production and other Ca2+ mobilizing agents. CRAC channels are responsible for medi-ating calcium influx in T-cells and play an important role in the immune response. Orai2 specifically increases the Ca2+-selective current through coaction with the Ca2+ sensor Stim1.
Function:
Ca(2+) release-activated Ca(2+)-like (CRASLClike) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, STIM1.
Subunit:
Interacts with EFCAB4B/CRACR2A.
Subcellular Location:
Membrane; Multi-pass membrane protein.
Similarity:
Belongs to the Orai family.
Database links:
Entrez Gene: 80228 Human
Entrez Gene: 269717 Mouse
Entrez Gene: 304592 Rat
Omim: 610929 Human
SwissProt: Q96SN7 Human
SwissProt: Q8SH10 Mouse
Unigene: 363308 Human
Unigene: 308396 Mouse
Unigene: 18207 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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