Rabbit Anti-Brain protein CG6/FITC Conjugated antibody

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Brain protein CG 6; Brain protein CG-6; Brain protein CG6; C9orf4; CG 6; CG6; chromosome 9 open reading frame 4; CI004_HUMAN; Uncharacterized protein C9orf4.

Cat:

SL9492R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human Brain protein CG6

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

37kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
C9orf4 is a 344 amino acid single-pass membrane protein that is primarily expressed in adult and fetal brain and is weakly expressed in spinal cord, adult ovary and medulla. C9orf4 contains one DOMON domain, a predominantly β-sheet domain that is thought to aide in extracellular adhesion. The gene encoding C9orf4 maps to human chromosome 9, which consists of about 145 million bases and 4% of the human genome and encodes nearly 900 genes. Considered to play a role in gender determination, deletion of the distal portion of 9p can lead to development of male to female sex reversal, the phenotype of a female with a male X,Y genotype. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, is associated with the chromosome 9 gene encoding endoglin protein, ENG. Familial dysautonomia is also associated with chromosome 9 though through the gene IKBKAP. Notably, chromosome 9 encompasses the largest interferon family gene cluster. Chromosome 9 is partnered with chromosome 22 in the translocation leading to the aberrant production of BCR-ABL fusion protein often found in leukemias.

Subunit:
Component of the outer core of AMPAR complex. AMPARcomplex consists of an inner core made of 4 pore-forming GluA/GRIAproteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliarysubunits arranged in a twofold symmetry. One of the two pairs ofdistinct binding sites is occupied either by CNIH2, CNIH3 orCACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 orGSG1L. This inner core of AMPAR complex is complemented by outercore constituents binding directly to the GluA/GRIA proteins atsites distinct from the interaction sites of the inner coreconstituents. Outer core constituents include at least PRRT1,PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the innerand outer core serve as a platform for other, more peripherallyassociated AMPAR constituents. Alone or in combination, theseauxiliary subunits control the gating and pharmacology of the AMPARcomplex and profoundly impact their biogenesis and proteinprocessing (By similarity).

Subcellular Location:
Cell membrane (By similarity). Celljunction, synapse (By similarity).

Tissue Specificity:
Expressed in adult and fetal brain. Very weak expression in medulla, spinal cord and in adult ovary.

Similarity:
Contains 1 DOMON domain.

Database links:

Entrez Gene: 23732 Human

Omim: 604574 Human

SwissProt: Q9P0K9 Human

Unigene: 347537 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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