Rabbit Anti-C9ORF46/FITC Conjugated antibody

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FLJ14688; AD025; Chromosome 9 open reading frame 46; FLJ39176; Hypothetical protein LOC55848; MDS030; transmembrane protein C9orf46; Uncharacterized hematopoietic stem/progenitor cells protein MDS030; PLRKT_HUMAN.

Cat:

SL9489R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human C9ORF46

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

17kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
C9orf46 is a 147 amino acid transmembrane protein. The gene encoding C9orf46 maps to human chromosome 9, which consists of about 145 million bases and 4% of the human genome and encodes nearly 900 genes. Considered to play a role in gender determination, deletion of the distal portion of 9p can lead to development of male to female sex reversal, the phenotype of a female with a male X,Y genotype. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, is associated with the chromosome 9 gene encoding endoglin protein, ENG. Familial dysautonomia is also associated with chromosome 9 though through the gene IKBKAP. Notably, chromosome 9 encompasses the largest interferon family gene cluster. Chromosome 9 is partnered with chromosome 22 in the translocation leading to the aberrant production of BCR-ABL fusion protein often found in leukemias.

Function:
Receptor for plasminogen. Regulates urokinaseplasminogen activator-dependent and stimulates tissue-typeplasminogen activator-dependent cell surface plasminogenactivation. Proposed to be part of a local catecholaminergic cellplasminogen activation system that regulates neuroendocrineprohormone processing. Involved in regulation of inflammatoryresponse; regulates monocyte chemotactic migration and matrixmetallproteinase activation, such as of MMP2 and MMP9.

Subunit:
Interacts with PLAT and PLAUR (By similarity).

Subcellular Location:
Cell membrane; Multi-pass membrane protein.Note=Colocalizes on the cell surface with urokinase plasminogenactivator surface receptor/PLAUR (By similarity).

Tissue Specificity:
Expressed in peripheral blood cells andmonocytes. Expressed in adrenal medulla.

Database links:

Entrez Gene: 55848 Human

SwissProt: Q9HBL7 Human

SwissProt: Q9D3P8 Mouse

Unigene: 584242 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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