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Rabbit Anti-C22orf28/FITC Conjugated antibody
background:
HSPC117, also known as C22orf28, is a 505 amino acid protein that is encoded by a gene which maps to human chromosome 22. A highly homologous protein identified in rodents, FAAP (focal adhesion associated protein), encoded by murine D10Wsu52e gene, has been suggested to play a role in regulating cell adhesion dynamics. Chromosome 22 houses over 500 genes and is the second smallest human chromosome. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, Neurofibromatosis type 2, autism and schizophrenia. Additionally, translocations between chromosomes 9 and 22 may lead to the formation of the Philadelphia Chromosome and the subsequent production of the novel fusion protein BCR-Abl, a potent cell proliferation activator found in several types of leukemias.
Function:
Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as a RNA ligase with broad substrate specificity, and may function toward other RNAs.
Subunit:
Catalytic component of the tRNA-splicing ligase complex.
Subcellular Location:
Cytoplasm.
Similarity:
Belongs to the RtcB family.
Database links:
Entrez Gene: 51493 Human
Entrez Gene: 28088 Mouse
Entrez Gene: 362855 Rat
Omim: 613901 Human
SwissProt: Q9Y3I0 Human
SwissProt: Q99LF4 Mouse
SwissProt: Q6AYT3 Rat
Unigene: 474643 Human
Unigene: 9257 Mouse
Unigene: 11875 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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