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Rabbit Anti-CREPT/FITC Conjugated antibody
background:
Interacts with phosphorylated SLCterminal heptapeptide
repeat domain (CTD) of the largest RNA polymerase II subunit
POLR2A, and participates in dephosphorylation of the CTD.
Transcriptional regulator which enhances expression of CCND1.
Promotes binding of RNA polymerase II to the CCDN1 promoter and to
the termination region before the poly-A site but decreases its
binding after the poly-A site. Prevents RNA polymerase II from
reading through the 3' end termination site and may allow it to be
recruited back to the promoter through promotion of the formation
of a chromatin loop. Also enhances the transcription of a number of
other cell cycle-related genes including CDK2, CDK4, CDK6 and
cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation.
Function:
Interacts with phosphorylated SLCterminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation.
Subunit:
Associates with the RNA polymerase II complex.
Subcellular Location:
Nucleus.
Tissue Specificity:
Preferentially expressed in a range of tumor tissues including colon, lung, liver, breast, prostate, stomach, uterine endometrium and cervical cancers with higher levels in tumors than in adjacent non-tumor tissue (at protein level).
Similarity:
Belongs to the UPF0400 (RTT103) family.
Contains 1 CID domain.
Database links:
Entrez Gene: 58490 Human
Entrez Gene: 70470 Mouse
Entrez Gene: 311591 Rat
Omim: 614694 Human
SwissProt: Q9NQG5 Human
SwissProt: Q9CSU0 Mouse
Unigene: 278839 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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