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Rabbit Anti-C20orf103/FITC Conjugated antibody
background:
Representing about 2% of human DNA, chromosome 20 consists of approximately 63 million bases and 600 genes. Chromosome 20 contains a region with numerous genes expressed in the epididymis, which are thought important for seminal production, and some viewed as potential targets for male contraception. The PRNP gene encoding the prion protein associated with spongiform encephalopathies, like Creutzfeldt-Jakob disease, is found on chromosome 20. Amyotrophic lateral sclerosis, spinal muscular atrophy, ring chromosome 20 epilepsy syndrome and Alagille syndrome are also associated with chromosome 20. The C20orf103 gene product has been provisionally designated C20orf103 pending further characterization.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Cytoplasmic vesicle (By similarity). Cell projection, dendrite (By similarity). Cell projection, growth cone membrane; Single-pass type I membrane protein (By similarity). Early endosome membrane; Single-pass type I membrane protein (By similarity). Recycling endosome (By similarity). Note=Localized mostly in cytoplasmic vesicles of neuronal cell body. Recycles from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane (By similarity). Colocalizes with UNC93B1 in large endosomal intracellular vesicles. Accumulates in the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) before its disappearance upon activation by CpG dinucleotides. Associates with cortical membranes.
Tissue Specificity:
Expressed in plasmocytoid dendritic cells. Expressed in suprabasal skin keratinocytes and squamous cells (at protein level). Expressed in the brain and weakly in spleen and skin. Expressed in plasmocytoid dendritic cells.
Post-translational modifications:
Glycosylated.
Similarity:
Belongs to the LAMP family.
Database links:
Entrez Gene: 24141 Human
Entrez Gene: 76161 Mouse
Entrez Gene: 36220 Rat
SwissProt: A4FV27 Cow
SwissProt: Q9UJQ1 Human
SwissProt: Q9D387 Mouse
SwissProt: Q5PPI4 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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