background:
May play a role in folate metabolism. Belongs to the dihydrofolate reductase family.
Function:
Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Binds its own mRNA and that of DHFR.
Subcellular Location:
Mitochondrion. Mitochondrion matrix. Mitochondrion inner membrane.
Tissue Specificity:
Expressed in numerous cell lines.
Similarity:
Belongs to the dihydrofolate reductase family.
Contains 1 DHFR (dihydrofolate reductase) domain.
Database links:
Entrez Gene: 200895 Human
SwissProt: Q86XF0 Human
Unigene: 718516 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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