background:
Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process.
Function:
Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process.
Subunit:
Interacts with GPX1 (By similarity).
Subcellular Location:
Cellular localizationCytoplasm; cytosol. Cell membrane. Concentrates at the leading edge of migrating cells. Localizes outside membrane raft regions.
Tissue Specificity:
Among normal tissues, present only in Leydig cells. Strongly up-regulated in breast cancers and in brain cancer distant metastasis (at protein level). Up-regulated in prostate cancer cells and in the higher grades of prostate adenocarcinoma (at protein level).
Post-translational modifications:
Isoprenylation facilitates association with the plasma membrane and enhances the migratory phenotype of cells by inducing increased filopodia formation.
Similarity:
Belongs to the SelWTH family.
Database links:
Entrez Gene: 84299 Human
Entrez Gene: 103742 Mouse
Entrez Gene: 72617 Rat
Omim: 62362 Human
SwissProt: Q9BRT3 Human
SwissProt: Q9CQ86 Mouse
Unigene: 333526 Human
Unigene: 259614 Mouse
Unigene: 143893 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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