background:
Imp3, is a 184 amino acid protein that contains one S4 RNA-binding domain and is the mammalian homolog of the yeast Imp3 protein. Localized to the nucleus, Imp3 exists as a component of a heterotrimeric complex consisting of MPP10, Imp3 and Imp4 and, in this complex, plays a key role in early cleavage events during pre-18S ribosomal processing. The gene encoding Imp3 maps to human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome. Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease and Marfan syndrome are all associated with defects in chromosome 15-localized genes.
Function:
Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.
Subunit:
Component of a heterotrimeric complex containing IMP3, IMP4 and MPHOSPH10. Interacts with MPHOSPH10.
Subcellular Location:
Nucleus, nucleolus.
Similarity:
Belongs to the ribosomal protein S4P family.
Contains 1 S4 RNA-binding domain.
Database links:
Entrez Gene: 55272 Human
Entrez Gene: 102462 Mouse
Entrez Gene: 315697 Rat
Omim: 61596 Human
SwissProt: Q9NV31 Human
SwissProt: Q921Y2 Mouse
Unigene: 513043 Human
Unigene: 12864 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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