background:
Poly(ADP-ribosylation) is a method of DNA damage-dependent posttranslational modification that helps to rescue injured proliferating cells from cell death. The PARP (poly(ADP-ribose) polymerase) proteins comprise a superfamily of enzymes that functionally modify histones and other nuclear proteins, thereby preventing cell death. PARPs use NAD+ as a substrate to catalytically transfer ADP-ribose residues onto protein acceptors; a process that, when repeated multiple times, leads to the formation of poly(ADPribose) chains on the protein. The presence of these chains alters the function of the target protein and promotes cell survival. PARP proteins are implicated in a variety of diseases, including cancer, neurodegenerative and inflammatory disorders. PARP-16 is a 322 amino acid poly (ADP-ribose) polymerase protein localized to the membrane. Expressed as three isoforms produced by alternative splicing, PARP-16 contains one PARP catalytic domain.
Function:
Mono-ADP-ribosyltransferase targeting the karyopherin KPNB1. Plays a role in unfolded protein response (UPR), by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors.
Subcellular Location:
Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
Post-translational modifications:
ADP-ribosylated (-auto).
Similarity:
Contains 1 PARP alpha-helical domain.
Contains 1 PARP catalytic domain.
Database links:
Entrez Gene: 54956 Human
Entrez Gene: 214424 Mouse
Entrez Gene: 315760 Rat
SwissProt: Q8N5Y8 Human
SwissProt: Q7TMM8 Mouse
SwissProt: Q5U2Q4 Rat
Unigene: 30634 Human
Unigene: 31129 Mouse
Unigene: 23423 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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