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Rabbit Anti-Dishevelled 3/FITC Conjugated antibody
background:
Mammalian homologs of the Drosophila dishevelled (Dsh) gene have been identified, including Dvl-1, Dvl-2 and Dvl-3. The mammalian dishevelled proteins contain three homologous domains, two of which are unrelated to any other known protein. The third region is homologous to the discs-large homology domain of Drosophila discs-large-1, a tumor suppressor protein. Like their Drosophila counterpart, the dishevelled proteins are thought to be in-volved in embryogenesis. Overexpression of Dvl-1 has been shown to inhibit the phosphorylation of tau by GSK-3b. This finding may prove to be important in Alzheimer’s studies, which have shown that tau is hyperphosphorylated. In Drosophila, Dsh is a component of the frizzled signaling pathway. Both mammalian dishevelled and frizzled proteins are components of the Wnt signalling pathway.
Function:
May play a role in the signal transduction pathway mediated by multiple Wnt genes.
Subunit:
Interacts (via the PDZ domain) with the SLCterminal regions of VANGL1 and VANGL2 (By similarity). Interacts (via the region containing both the PDZ and DEP domains) with LRRFIP2; the DIX domain may inhibit this interaction. Interacts with CYLD, CEP164 and DAB2.
Subcellular Location:
Cytoplasm.
Post-translational modifications:
Ubiquitinated. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains.
Phosphorylated by CSNK1D.
Similarity:
Belongs to the DSH family.
Contains 1 DEP domain.
Contains 1 DIX domain.
Contains 1 PDZ (DHR) domain.
Database links:
Entrez Gene: 1857 Human
Entrez Gene: 13544 Mouse
Entrez Gene: 303811 Rat
Omim: 601368 Human
SwissProt: Q92997 Human
SwissProt: Q61062 Mouse
Unigene: 388116 Human
Unigene: 247259 Mouse
Unigene: 272443 Mouse
Unigene: 219497 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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