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Rabbit Anti-PISF1/FITC Conjugated antibody
background:
PISF is synthesized during pregnancy in response to progesterone by progesterone receptor-positive T lymphocytes (mostly gamma-delta T cells). In the presence of PISF, natural killer (NK) cells inhibit the release of perforin from storage granules and therefore fail to lyse target cells. In humans, the amount of cells that express PISF is significantly higher in healthy pregnant women than in women at risk for premature pregnancy termination. Full-length PISF is associated with the nucleus, whereas secretion of shorter forms is induced by activation of the cell. Research suggests that PISF functions as a transcription factor in its full-length form, while smaller forms may act as cytokines. The PISF gene encodes a deduced hydrophilic 757-amino acid alpha-helical protein with an N-terminal signal sequence, a leucine zipper motif, a basic zipper sequence, a PEST sequence, a nuclear localization signal, an endoplasmic reticulum membrane retention signal, and many presumeed N-glycosylation and phosphorylation sites.
Function:
Mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling NK activity exerts an anti-abortive effect.
Tissue Specificity:
Expressed at highest levels in testis. Moderate expression is detected in spleen, thymus, prostate, ovary, small intestine, and colon.
Database links:
Entrez Gene: 10464 Human
Entrez Gene: 52023 Mouse
Omim: 607532 Human
SwissProt: Q8WXW3 Human
Unigene: 441926 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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