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Rabbit Anti-Transcription factor 25/FITC Conjugated antibody
background:
Transcription factor 25 acts as a transcriptional repressor. It has been shown to repress transcription of SRF in vitro and hence may play a role in heart development.Transcription factor 25, is a 676 amino acid protein that plays a role in cell death. A member of the TCF25 family, Nulp1 utilizes its SLCterminus to mediate transcriptional repression of SRF in vitro, and interacts with XIAP. Nulp1 localizes primarily to the nucleus but is also found in cytosol. Widely expressed, Nulp1 is found at high levels in embryonic brain and adult heart. The gene encoding Nulp1 maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.
Function:
May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart development.
Subunit:
Interacts with XIAP (By similarity).
Subcellular Location:
Nuclear. Note=Some staining in the cytosol.
Tissue Specificity:
In the embryo, widely expressed with highest levels in brain. In the adult, highest expression is found in the heart.
Similarity:
Belongs to the TCF25 family.
Database links:
Entrez Gene: 2596 Human
Entrez Gene: 66855 Mouse
Omim: 612326 Human
SwissProt: Q9BQ70 Human
SwissProt: Q8R3L2 Mouse
Unigene: 415342 Human
Unigene: 178818 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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