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Rabbit Anti-TEF3/FITC Conjugated antibody
background:
TEF-3, is a 427 amino acid member of the transcriptional enhancer factor (TEF) family of proteins that are characterized by the presence of a TEA DNA-binding domain. Localized to the nucleus and expressed primarily in skeletal muscle, TEF-3 functions as a transcriptional regulator by binding specifically and non-cooperatively to the M-CAT motif found in the promotors of muscle-specific genes, thereby directing their subsequent expression. TEF-3 contains one TEA DNA-binding domain and is expressed as multiple isoforms due to alternative splicing events.
Function:
ranscription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.
Subunit:
Interacts with YAP1 and WWTR1/TAZ.
Subcellular Location:
Nucleus.
Tissue Specificity:
Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart.
Similarity:
Contains 1 TEA DNA-binding domain.
Database links:
Entrez Gene: 7004 Human
Entrez Gene: 21679 Mouse
Omim: 601714 Human
SwissProt: Q15561 Human
SwissProt: Q62296 Mouse
Unigene: 94865 Human
Unigene: 14774 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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