Rabbit Anti-CMYA2/PDE4DIP/FITC Conjugated antibody

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Cardiomyopathy associated protein 2; Cardiomyopathy-associated protein 2; CMYA2; MMGL; MYOME_HUMAN; Myomegalin; Pde4dip; Phosphodiesterase 4D interacting protein; Phosphodiesterase 4D-interacting protein.

Cat:

SL9477R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human CMYA2/PDE4DIP

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

265kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
May function as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes. Myomegalin, is a 2,346 amino acid protein that contains one NBPF domain and localizes to the nucleus, cytoplasm, centrosome and Golgi apparatus. Expressed at high levels in fetal and adult heart and at lower levels in brain and placenta, myomegalin is thought to function as an anchoring protein that sequesters members of the cAMP-dependent pathway to the Golgi and to centrosomes, thereby mediating cAMP pathway dynamics. Translocations in the gene that encodes myomegalin are associated with myeloproliferative disorders (MBDs), a group of diseases caused by an overproduction of blood cells. Myomegalin exists as twelve isoforms due to alternative splicing events.

Function:
May function as an anchor sequestering components of thecAMP-dependent pathway to Golgi and/or centrosomes (By similarity).

Subunit:
Interacts with PDE4D (By similarity).

Subcellular Location:
Golgi apparatus (By similarity). Cytoplasm,cytoskeleton, centrosome (By similarity). Cytoplasm. Nucleus.

Tissue Specificity:
Highly expressed in heart and skeletal muscle and to a lower extent in brain and placenta.

DISEASE:
Note=A chromosomal aberration involving PDE4DIP may bethe cause of a myeloproliferative disorder (MBD) associated witheosinophilia. Translocation t(1;5)(q23;q33) that forms aPDE4DIP-PDGFRB fusion protein.

Similarity:
Contains 1 NBPF domain.

Database links:

Entrez Gene: 9659 Human

Entrez Gene: 83679 Mouse

Entrez Gene: 64183 Rat

Omim: 608117 Human

SwissProt: Q5VU43 Human

SwissProt: Q80YT7 Mouse

SwissProt: Q9WUJ3 Rat

Unigene: 584841 Human

Unigene: 613082 Human

Unigene: 657490 Human

Unigene: 728768 Human

Unigene: 129168 Mouse

Unigene: 48693 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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