background:
Transcriptional factor that uses the canonical single or multiple CArG boxes DNA sequence. Binds CArG boxes only in the presence of serum response factor (SRF). Acts as a cofactor of SRF and modulates SRF-target genes. Regulates the expression of a set of cardiac and smooth muscle-specific genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage.
Function:
Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis).
Subunit:
Homodimer. Interacts with SRF, its association does not depend on specific DNA sequences for ternary complex formation. Interacts with MLLT7/FOXO4. Interacts (via SLCterminal) with EP300 (via the CREB-binding domain). Interacts with HDAC4 and HDAC5 (By similarity). Interacts with MEF2C.
Subcellular Location:
Nucleus.
Tissue Specificity:
Expressed in heart, aorta, and in smooth muscle cell-containing tissues: stomach, bladder, small intestine, colon, lung, placenta and uterus. Very faint expression in prostate and skeletal muscle.
Post-translational modifications:
Phosphorylation regulates negatively the intrinsic myocardin transcriptional activity.
Similarity:
Contains 3 RPEL repeats.
Contains 1 SAP domain.
Database links:
Entrez Gene: 93649 Human
Entrez Gene: 214384 Mouse
Entrez Gene: 396571 Pig
Entrez Gene: 246297 Rat
Omim: 606127 Human
SwissProt: Q8IZQ8 Human
SwissProt: Q8VIM5 Mouse
SwissProt: Q8R5I7 Rat
Unigene: 567641 Human
Unigene: 32257 Mouse
Unigene: 163103 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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