background:
TNNI3K, also known as CARK, is a 936 amino acid serine/threonine-protein kinase that is highly expressed in heart. Overexpression of TNNI3K leads to improved cardiac function by enhancing beating frequency and increasing contractile force and epinephrine response. TNNI3K suppresses phosphorylation of cardiac troponin I and p38/JNK-mediated apoptosis, therefore protecting the myocardium from ischemic injury. Administration of TNNI3K to mice with myocardial infarction improves cardiac performance and attentuates ventricular remodeling, suggesting that TNNI3K could be a promising target in the treatment of cardiac diseases. There are four isoforms of TNNI3K that are produced as a result of alternative splicing events.
Function:
May play a role in cardiac physiology.
Subunit:
Interacts with TNNI3, ACTC, ACTA1, MYBPC3, AIP, BABP3 and HADHB.
Subcellular Location:
Nucleus. Cytoplasm. Expressed at lower levels in the cytoplasm.
Tissue Specificity:
Highly expressed in both adult and fetal heart.
Post-translational modifications:
Autophosphorylated.
Similarity:
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Contains 10 ANK repeats.
Contains 1 protein kinase domain.
Database links:
Entrez Gene: 51086 Human
Entrez Gene: 435766 Mouse
Entrez Gene: 295531 Rat
SwissProt: Q59H18 Human
SwissProt: Q5GIG6 Mouse
SwissProt: Q7TQP6 Rat
Unigene: 72964 Human
Unigene: 210428 Mouse
Unigene: 3434 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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