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Rabbit Anti-Hexokinase II/FITC Conjugated antibody
background:
The hexokinases utilize Mg-ATP as a phosphoryl donor to catalyze the first step of intracellular glucose metabolism, the conversion of glucose to glucose-6-phosphate. Four hexokinase isoenzymes have been identified, including hexokinase I (HXK I), hexokinase II (HXK II), hexokinase III (HXK III) and hexokinase IV (HXK IV, also designated glucokinase or GCK). Hexokinases I-III each contain an N-terminal cluster of hydrophobic amino acids. Glucokinase lacks the N-terminal hydrophobic cluster. The hydrophobic cluster is thought to be necessary for membrane binding. This is substantiated by the finding that glucokinase has lower affinity for glucose than do the other hexokinases. HXK I has been shown to be expressed in brain, kidney and heart tissues as well as in hepatoma cell lines. HXK II is involved in the uptake and utilization of glucose by adipose and skeletal tissues. Of the hexokinases, HXK III has the highest affinity for glucose. Glucokinase is expressed in pancreatic beta cells where it functions as a glucose sensor, determining the “set point” for insulin secretion.
Subunit:
Monomer (By similarity).
Subcellular Location:
Mitochondrion outer membrane. Its hydrophobic N-terminal sequence may be involved in membrane binding.
Tissue Specificity:
Predominant hexokinase isozyme expressed in insulin-responsive tissues such as skeletal muscle.
Similarity:
Belongs to the hexokinase family.
Database links:
Entrez Gene: 3099 Human
Omim: 601125 Human
SwissProt: P52789 Human
Unigene: 406266 Human
Unigene: 591588 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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