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Rabbit Anti-BMP10/FITC Conjugated antibody
background:
Bone morphogenic proteins (BMPs) are members of the TGF beta superfamily and are involved in the induction of cartilage and bone formation. BMP-10 (Bone morphogenetic protein 10) is a 424 amino acid secreted protein that exists as a disulfide-linked homodimer. Expressed specifically in heart tissue, BMP-10 functions to prevent the premature activation of p57 (a negative cell cycle regulator), thereby maintaining the proliferative activity of embryonic cardiomyocytes and playing a critical role in the formation of trabeculae within the developing heart. Additionally, BMP-10 inhibits the growth and migration of endothelial cells and functions as a ligand for ALK-1, a protein that is tightly linked to angiogenesis. This suggests that, in addition to its role in cardiomyocyte formation, BMP-10 participates in the formation of blood vessels in developing cardiac muscle.
Function:
Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth.
Subunit:
Homodimer; disulfide-linked.
Subcellular Location:
Secreted.
Similarity:
Belongs to the TGF-beta family.
Database links:
Entrez Gene: 27302 Human
Entrez Gene: 12154 Mouse
Entrez Gene: 500245 Rat
Omim: 608748 Human
SwissProt: O95393 Human
SwissProt: Q9R229 Mouse
SwissProt: Q4AEG6 Rat
Unigene: 158317 Human
Unigene: 483321 Mouse
Unigene: 23610 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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