background:
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.
Function:
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.
Subunit:
Interacts with FEM1A.
Subcellular Location:
Cell membrane.
Tissue Specificity:
High in intestine and in peripheral blood mononuclear cells; low in lung, kidney, thymus, uterus, vasculature and brain. Not found in liver, heart, retina oe skeletal muscle.
Post-translational modifications:
Phosphorylation mediates agonist-mediated desensitization by promoting cytoplasmic retention.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
Database links:
Entrez Gene: 5734 Human
Entrez Gene: 19219 Mouse
Entrez Gene: 16823 Rat
Entrez Gene: 443222 Sheep
Omim: 601586 Human
SwissProt: P35408 Human
SwissProt: P3248 Mouse
SwissProt: P43114 Rat
Unigene: 199248 Human
Unigene: 18509 Mouse
Unigene: 16062 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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