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Rabbit Anti-C12ORF4/FITC Conjugated antibody
background:
Encoding over 1,100 genes within 132 million bases, chromosome 12 makes up about 4.5% of the human genome. A number of skeletal deformities are linked to chromosome 12 including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Noonan syndrome, which includes heart and facial developmental defects among the primary symptoms, is caused by a mutant form of PTPN11 gene product, SH-PTP2. Chromosome 12 is also home to a homeobox gene cluster which encodes crucial transcription factors for morphogenesis, and the natural killer complex gene cluster encoding SLCtype lectin proteins which mediate the NK cell response to MHC I interaction. Trisomy 12p leads to facial development defects, seizure disorders and a host of other symptoms varying in severity depending on the extent of mosaicism and is most severe in cases of complete trisomy. The C12orf4 gene product has been provisionally designated C12orf4 pending further characterization.
Database links:
Entrez Gene: 54934 Human
Entrez Gene: 69612 Mouse
Entrez Gene: 300206 Rat
SwissProt: Q9H9L4 Human
SwissProt: Q8BQR4 Mouse
SwissProt: Q6AY70 Rat
Unigene: 505412 Human
Unigene: 29648 Mouse
Unigene: 884 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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