background:
HARBI1 is a 349 amino acid nuclear and cytoplasmic protein belonging to the HARBI1 family. Members of the HARBI1 family of proteins are highly conserved in humans to various bony fish. Considered a transposase-derived protein, HARBI1 may possess nuclease activity and is expressed in brain, eye, nerve tissue, kidney and lung. HARBI1 utilizes divalent metal cations as cofactors, interacts with NAIF1 and promotes translocation to the nucleus. HARBI1 is encoded by a gene located on human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that maps to chromosome 11.
Function:
Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.
Subunit:
Interacts with NAIF1.
Subcellular Location:
Nucleus. Cytoplasm. Interaction with NAIF1 promotes translocation to the nucleus.
Tissue Specificity:
Detected in brain, eye, nerve tissue, kidney and lung.
Similarity:
Belongs to the HARBI1 family.
Database links:
Entrez Gene: 283254 Human
Entrez Gene: 241547 Mouse
Entrez Gene: 690164 Rat
SwissProt: Q96MB7 Human
SwissProt: Q8BR93 Mouse
SwissProt: B0BN95 Rat
Unigene: 714463 Human
Unigene: 130331 Mouse
Unigene: 198635 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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