Rabbit Anti-UVRAG/FITC Conjugated antibody

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DHTX; Disrupted in heterotaxy; p63; UV radiation resistance associated; UV radiation resistance associated gene; UV radiation resistance associated gene protein; UV radiation resistance-associated gene protein; UVRAG; UVRAG_HUMAN.

Cat:

SL9923R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from Human UVRAG/DHTX

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

78kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
UVRAG, also known as p63 or DHTX, is a 699 amino acid cytoplasmic protein. UVRAG has been shown to activate the BECN1/PI 3-kinase complex, which promotes autophagy. Autophagy is the degradation of cellular proteins in the lysosomes, and when this pathway is suppressed, cell growth is deregulated. Mutations in the gene encoding UVRAG have been associated with colon cancer, suggesting that UVRAG is also involved in suppressing the proliferation and tumorigenicity of human colon cancer cells. UVRAG has been found to complement the ultraviolet sensitivity of xeroderma pigmentosum group C cells. Ubiquitously expressed, UVRAG is found at highest levels in kidney, lung, liver and brain. UVRAG contains one C2 domain, which is thought to be involved in calcium-dependent phospholipid binding.

Subunit:
Forms a complex with BECN1, PIK3C3 and PIK3R4. A subpopulation of these complexes also harbor KIAA0226/Rubicon. UVRAG-containing complexes never including ATG14, both forming mutually exclusive complexes with BECN1 through direct competition. Directly interacts with FEZ1 and SCOC. The interaction with SCOC is reduced by amino acid starvation, but the complex is stabilized in the presence of FEZ1.

Subcellular Location:
Late endosome. Lysosome. Early endosome. Colocalizes with RAB9-positive compartments involved in retrograde transport from late endosomes to trans-Golgi network. Colocalization with early endosomes is only partial.

Tissue Specificity:
Highly expressed in brain, lung, kidney and liver.

DISEASE:
Note=A chromosomal aberration involving UVRAG has been observed in a patient with heterotaxy (left-right axis malformation). Inversion Inv(11)(q13.5;q25).

Similarity:
Contains 1 C2 domain.

Database links:

Entrez Gene: 7405 Human

Entrez Gene: 78610 Mouse

Omim: 602493 Human

SwissProt: Q9P2Y5 Human

Unigene: 728868 Human

Unigene: 323072 Mous

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

UVRAG肿瘤抑制基因可对自体吞噬起到调控机制，以完成自我运输调节机制。此外，UVRAG肿瘤抑制因子还是包膜上物质转运通路上的重要效应蛋白，它可调控细胞的内吞和自体吞噬作用。

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