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Rabbit Anti-G protein alpha Inhibitor 2/FITC Conjugated antibody
background:
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division.
Function:
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division.
Isoform sGi2: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool.
Subunit:
G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with GPSM1. Interacts with RGS12 and RGS14. Interacts with UNC5B.
Subcellular Location:
Cytoplasm. Cytoplasm, cytoskeleton, centrosome. Cell membrane. Note=Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody.
Similarity:
Belongs to the G-alpha family. G(i/o/t/z) subfamily.
Database links:
Entrez Gene: 2771 Human
Entrez Gene: 14678 Mouse
Entrez Gene: 81664 Rat
Omim: 13972 Human
SwissProt: P04899 Human
SwissProt: P08752 Mouse
SwissProt: P04897 Rat
Unigene: 77269 Human
Unigene: 196464 Mouse
Unigene: 3036 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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