background:
GGT6 belongs to the gamma-glutamyltransferase family. GGT is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione synthesis. GGT6 has very limited amino acid similarity to GGT1 and it's enzymatic activities are currently uncharacterized. GGT assays are of current widespread clinical use to help assess tissue damage.
Function:
Cleaves glutathione conjugates
Subunit:
Heterodimer composed of the light and heavy chains. The active site is located in the light chain (By similarity).
Subcellular Location:
Membrane; Single-pass type II membrane protein.
Similarity:
Belongs to the gamma-glutamyltransferase family.
Database links:
Entrez Gene: 124975 Human
Omim: 612341 Human
SwissProt: Q6P531 Human
Unigene: 130749 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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