background:
Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology.
Function:
Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology.
Subunit:
Forms homooligomers and heterooligomers with SCUBE2 and SCUBE3.
Subcellular Location:
Secreted. Cell membrane.
Tissue Specificity:
Detected in endothelial cells. Highly expressed in platelets. Stored in platelet alpha granules, and transferrred to the cell surface upon activation and aggregation. A smaller form, probably produced by limited proteolysis, after being released from the storage granules, is associated with thrombus and localized with the subendothelial matrices in atherosclerotic plaques.
Post-translational modifications:
N-glycosylated.
Could be proteolytically cleaved to release a smaller active fragment.
Similarity:
Contains 1 CUB domain.
Contains 9 EGF-like domains.
Database links:
Entrez Gene: 80274 Human
Entrez Gene: 64706 Mouse
Entrez Gene: 100524621 Pig
Entrez Gene: 315174 Rat
Omim: 611746 Human
SwissProt: Q8IWY4 Human
SwissProt: Q6NZL8 Mouse
Unigene: 133995 Human
Unigene: 40393 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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