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Rabbit Anti-p47/NSFL1C/FITC Conjugated antibody
background:
Platelet P47, also known as NSFL1C, UBX1, UBXD10 or UBXN2C, is a 370 amino acid protein that localizes to both the nucleus and the golgi apparatus (specifically to golgi stacks) and contains one SEP domain and one UBX domain. Functioning as part of a ternary complex with VCP (a protein involved in the heterotypic fusion of transport vesicles with their target membranes) and Syntaxin 5, p47 interacts with and reduces the ATPase activity of VCP and is required for the fragmentation of golgi stacks during mitosis and for subsequent reassembly of golgi stacks after mitosis. p47 is subject to phosphorylation during mitosis, which inhibits p47-golgi interaction and is, therefore, required for proper golgi stack formation and cisternal regrowth. Human p47 shares 89% sequence identity with its mouse counterpart, suggesting a conserved role between species. Multiple isoforms of p47 exist due to alternative splicing events.
Function:
Major protein kinase C substrate of platelets.
Subcellular Location:
Nucleus. Golgi apparatus > Golgi stack. Chromosome. Predominantly nuclear in interphase cells. Bound to the axial elements of sex chromosomes in pachytene spermatocytes. A small proportion of the protein is cytoplasmic, associated with Golgi stacks.
Tissue Specificity:
Major protein kinase C substrate of platelets.
Post-translational modifications:
Phosphorylated during mitosis. Phosphorylation inhibits interaction with Golgi membranes and is required for the fragmentation of the Golgi stacks during mitosis.
Similarity:
Contains 1 DEP domain.
Contains 2 PH domains.
Database links:
Entrez Gene: 5341 Human
Entrez Gene: 56193 Mouse
Omim: 173570 Human
SwissProt: Q6Q308 Dog
SwissProt: P08567 Human
SwissProt: Q9JHK5 Mouse
Unigene: 468168 Human
Unigene: 98232 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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