Rabbit Anti-Cappuccino/FITC Conjugated antibody

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Cappuccino; Cappuccino homolog; Cappuccino homolog; FLJ11230; Protein cappuccino; Protein cappuccino homolog; BL1S4_HUMAN; Biogenesis of lysosome-related organelles complex 1 subunit 4; BLOC-1 subunit 4; BLOC1S4; BCAS4L; CNO.

Cat:

SL9895R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Horse,Sheep,Guinea Pig,)

Immunogen：

KLH conjugated synthetic peptide derived from human Cappuccino

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

27kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Biogenesis of lysosome-related organelles complex-1 (BLOSLC1) is a multisubunit protein necessary for biogenesis of specialized organelles of the endosomal-lysosomal system (such as melanosomes and platelet-dense granules). The complex consists of coiled-coil-forming proteins Snapin, Pallidin, Cappuccino, Muted, BLOS1, BLOS2, and BLOS3. The localization of these proteins varies as they can be cytoplasmic, peripheral membrane bound or anchored to the vesicular membrane.Cappuccino, a primarily cytoplasmic protein, plays a role in the development of melanosomes, platelet-dense granules and other lysosome-related organelles. It interacts primarily with pallidin and Muted and has been implicated as an actin-nucleation factor that may play a role in crosstalk between microfilaments and microtubules.

Function:
Component of the BLOSLC1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOSLC1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOSLC1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking.

Subunit:
Interacts with BLOC1S5 and BLOC1S6. Component of the biogenesis of lysosome-related organelles complex 1 (BLOSLC1) composed of BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. Octamer composed of one copy each BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. The BLOSLC1 complex associates with the AP-3 protein complex and membrane protein cargos.

Subcellular Location:
Cytoplasmic.

Tissue Specificity:
The intronless CNO (Cappuccino) gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. Mouse CNO is a component of a protein complex termed biogenesis of lysosome-related organelles complex 1 (BLOSLC1), and is a model for Hermansky-Pudlak syndrome. The CNO protein may play a role in intracellular vesicular trafficking.

Similarity:
Cytoplasm.

Database links:

Entrez Gene: 55330 Human

Omim: 605695 Human

SwissProt: Q9NUP1 Human

Unigene: 7570 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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