background:
Sorcin is a highly conserved protein, with 95% homology between hamster and human sorcin sequences. Sorcin has four putative Ca-binding domains, two of which exhibit strong homology to calmodulin “EF hand” motifs. Calcium binding directly to sorcin has been demonstrated by in vitro assays. Sorcin is closely related to members of calpain and sarcoplasmic Ca2+-binding protein subfamilies. Sorcin undergoes calcium-dependent translocation from the cytosol to cellular membranes. Sorcin binds to and modulates ryanodine receptors and is widely distributed including heart and brain tissues. At the subcellular level, sorcin localizes to T-tubule junctions of cardiac sarcoplasmic reticulum.
Function:
Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels.
Subunit:
Homodimer. Interacts with GCA, RYR2 and ANXA7.
Subcellular Location:
Cytoplasm. Sarcoplasmic reticulum membrane. Relocates to the sarcoplasmic reticulum membrane in response to elevated calcium levels.
Tissue Specificity:
Detected in cardiac myocytes.
Similarity:
Contains 4 EF-hand domains.
Database links:
Entrez Gene: 6717 Human
Entrez Gene: 109552 Mouse
Entrez Gene: 683667 Rat
Omim: 182520 Human
SwissProt: P30626 Human
SwissProt: Q6P069 Mouse
Unigene: 489040 Human
Unigene: 96211 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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