Rabbit Anti-Thymosin beta 4/FITC Conjugated antibody

Home > Product > Antibody > Rabbit Anti-Thymosin beta 4/FITC Conjugated antibody

Tβ4; FX; Hematopoietic system regulatory peptide; Prothymosin beta 4; PTMB 4; PTMB4; Seraspenide; T beta 4; T beta-4; TB4X; THYB 4; Thyb4; Thymosin beta 4; Thymosin beta 4 X chromosome; Thymosin beta 4 X linked; TMSB 4; TMSB4; TMSB4X; TYB4_HUMAN.

Cat:

SL9870R-FITC

Species Reactivity：

Mouse,(predicted: Human,Rat,)

Immunogen：

KLH conjugated synthetic peptide derived from human Thymosin beta 4

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

4.8kDa

prev next

Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

background:
Proteins in the thymosin beta family are highly conserved polar peptides that bind monomeric Actin and thereby inhibit Actin polymerization. These proteins act as the main intracellular G-Actin sequestering peptides. The most abundant thymosin beta family member in mammalian cells and tissues is thymosin beta-4 (Tbeta-4), also designated Seraspenide. T beta-4 participates in several cellular events including cancerogenesis, apoptosis, angiogenesis, blood coagulation and would healing. Specifically, T beta-4 promotes cell migration and adhesion, accelerates wound healing and reduces inflammation, and becomes upregulated in a wide variety of human carcinomas. Due to the effects of T beta-4 in these events, it may become a protein of significant biological and pharmaceutical relevance.

Function:
Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
Seraspenide inhibits the entry of hematopoietic pluripotent stem cells into the S-phase.

Subcellular Location:
Cytoplasm, cytoskeleton.

Tissue Specificity:
Originally found in thymus but it is widely distributed in many tissues.

Similarity:
Belongs to the thymosin beta family.

Database links:

Entrez Gene: 7114 Human

Entrez Gene: 19241 Mouse

Entrez Gene: 81814 Rat

Omim: 300159 Human

SwissProt: P62327 Horse

SwissProt: P62328 Human

SwissProt: P20065 Mouse

SwissProt: P62329 Rat

SwissProt: Q0P5V6 Rat

Unigene: 437277 Human

Unigene: 142729 Mouse

Unigene: 409203 Mouse

Unigene: 33667 Rat

Unigene: 2605 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Product Feedback Wall