Rabbit Anti-KCNG2/FITC Conjugated antibody

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Cardiac potassium channel subunit; KCNG2; KCNG2_HUMAN; KV6.2; Potassium voltage-gated channel subfamily G member 2; Voltage-gated potassium channel subunit Kv6.2.

Cat:

SL9857R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Pig,Cow,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human KCNG2

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

51kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Neuronal and cardiac cells are excited by voltage-gated ion channels. Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles and other excitable cells. Mutations interfering with potassium ion channels are known to cause a variety of disorders. KCNG2 (potassium voltage-gated channel subfamily G member 2) is also known as voltage-gated potassium channel subunit KV6.2, cardiac potassium channel subunit or KCNF2 and is a 466 amino acid protein. KCNG2 is a multi-pass membrane protein abundantly expressed in heart, liver, skeletal muscle, kidney and pancreas, and detected at lower concentrations in brain, lung and placenta. KCNG2 is an electrically silent subunit that forms heterodimers with KV2.1, creating a unique functional K+ channel. KCNG2-KV2.1 heterodimers are known to be inhibited by tetraethylammonium and propafenone. KCNG2 is thought to downregulate potassium channel currents because KCNG2-KV2.1 heterodimers generate smaller currents than KV2.1 homodimers

Function:
Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values.

Subunit:
Heterodimer with KCNB1. Does not form homomultimers.

Subcellular Location:
Membrane.

Tissue Specificity:
Highly expressed in heart, liver, skeletal muscle, kidney and pancreas. Detected at low levels in brain, lung and placenta.

Similarity:
Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.2/KCNG2 sub-subfamily.

Database links:

Entrez Gene: 26251 Human

Entrez Gene: 48444 Mouse

Entrez Gene: 307234 Rat

Omim: 605696 Human

SwissProt: Q9UJ96 Human

SwissProt: Q9QYU3 Rat

Unigene: 247905 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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