Rabbit Anti-HCN3/FITC Conjugated antibody

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Hcn3; HCN3_HUMAN; hyperpolarization activated cyclic nucleotide-gated potassium channel 3; KIAA1535; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3.

Cat:

SL9856R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Cow,Horse,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human HCN3

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

86kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Hyperpolarization-activated, cyclic nucleotide-binding channels (HCN) are voltage-gated cation channels that are activated by direct binding of intracellular cyclic nucleotides. The HCN family consists of four members (HCN1-4), each with a core transmembrane segment domain and a SLCterminal 120 amino-acid cyclic nucleotide-binding domain motif. HCN channels are expressed in the brain, heart, thalamus and testis. The pacemaker properties of HCN channels contribute to spontaneous rhythmic activity in the brain and heart. HCN3 contains a segment characterized by a series of positively charged amino acids at every third position. This region designated S4 is likely to be the voltage sensor of the protein. In the brain, HCN3 and HCN4 exhibit subcortical distribution mainly concentrated in the hypothalamus and thalamus, respectively.

Function:
Putative hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions (By similarity).

Subunit:
The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Similarity:
Belongs to the potassium channel HCN family.
Contains 1 cyclic nucleotide-binding domain.

Database links:

Entrez Gene: 57657 Human

Entrez Gene: 15168 Mouse

Entrez Gene: 114245 Rat

Omim: 609973 Human

SwissProt: Q9P1Z3 Human

SwissProt: O88705 Mouse

SwissProt: Q9JKA8 Rat

Unigene: 706960 Human

Unigene: 389461 Mouse

Unigene: 41761 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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