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Rabbit Anti-BAALC/FITC Conjugated antibody
background:
BAALC is a 36 amino acid protein that localizes to both the membrane and the cytoplasm and exists as multiple alternatively spliced isoforms. Expressed by hematopoetic and neural cells, BAALC interacts with CaMKII and is thought to play a role in synaptic function at postsynaptic lipid rafts. BAALC may be overexpressed in acute myeloid leukemia (AML), suggesting a role in tumorigenesis. The gene encoding BAALC maps to human chromosome 8, which consists of nearly 146 million base pairs, houses more than 800 genes and is associated with a variety of diseases and malignancies. Schizophrenia, bipolar disorder, Trisomy 8, Pfeiffer syndrome, congenital hypothyroidism, Waardenburg syndrome and some leukemias and lymphomas are thought to occur as a result of defects in specific genes that maps to chromosome 8.
Function:
May play a synaptic role at the postsynaptic lipid rafts by interacting with CAMK2A (By similarity).
Subunit:
Interacts with CAMK2A (By similarity).
Subcellular Location:
Cytoplasm. Membrane. Postsynaptic lipid rafts.
Tissue Specificity:
Expressed by neural and hematopoietic cells. Expression is found both in normal early progenitor cells and in the most immature type of blasts in acute leukemia but not in mature hematopoietic cells. Isoform 2 and isoform 6 are expressed in the brain. Isoform 2 shows a low expression in neuroectoderm-derived tissues such as adrenal gland and no expression in bone marrow, peripheral blood lymphocytes or lymph nodes, or in tumors or cancer cell lines of nonneural tissue origin.
Post-translational modifications:
Palmitoylation and myristoylation target the protein to the lipid rafts (By similarity).
Database links:
Entrez Gene: 79870 Human
Omim: 606602 Human
SwissProt: Q8WXS3 Human
Unigene: 533446 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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