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Rabbit Anti-GDN/FITC Conjugated antibody
background:
The serine protease inhibitors (serpins) compose a superfamily of proteins with a diverse set of functions, including the control of blood coagulation, complement activation, programmed cell death and development. Serpins are secreted glycoproteins that contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. Protease nexin-1 (PN-1) is a serpin that inactivates several proteases, including thrombin, urokinase, plasminogen activators (PA) and plasmin. It is involved in tissue remodeling, cellular invasiveness, matrix degradation and tumor growth. PN-1 expression is abundant in the nervous system, where it inhibits thrombin, thereby playing a role in neural injury and repair processes. An imbalance between PN-1 and thrombin may be a contributing factor in the pathology of Alzheimer’s disease.
Function:
Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.
Subcellular Location:
Secreted, extracellular space.
Similarity:
Belongs to the serpin family.
Database links:
Entrez Gene: 5270 Human
Entrez Gene: 20720 Mouse
Entrez Gene: 29366 Rat
Omim: 177010 Human
SwissProt: P07093 Human
SwissProt: Q07235 Mouse
SwissProt: P07092 Rat
Unigene: 38449 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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