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Rabbit Anti-KCC2/FITC Conjugated antibody
background:
K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Sep 2008]
Function:
Mediates electroneutral potassium-chloride cotransport in mature neurons. Transport occurs under isotonic conditions, but is activated 20-fold by cell swelling. Important for Cl(-) homeostasis in neurons.
Subunit:
Homomultimer and heteromultimer with other K-Cl cotransporters. Interacts with AP2A1.
Subcellular Location:
Membrane; Multi-pass membrane protein.
Tissue Specificity:
Brain specific. Detected in neuronal cells.
Similarity:
Belongs to the SLC12A transporter family.
Database links:
Entrez Gene: 57468 Human
Entrez Gene: 57138 Mouse
Entrez Gene: 171373 Rat
Omim: 606726 Human
SwissProt: Q9H2X9 Human
SwissProt: Q91V14 Mouse
SwissProt: Q63633 Rat
Unigene: 21413 Human
Unigene: 252987 Mouse
Unigene: 10513 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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