background:
C3orf21, also known as FLJ35155, is a 393 amino acid single-pass membrane protein that exists as three alternatively spliced isoforms. C3orf21 is encoded by a gene that maps to human chromosome 3q29. Chromosome 3 is made up of approximately 214 million bases encoding over 1,100 genes. Notably, there is a chemokine receptor gene cluster and a variety of human cancer related loci on chromosome 3. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells. Key tumor suppressing genes on chromosome 3 encode apoptosis mediator RASSF1, cell migration regulator HYAL1 and angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth disease are a few of the numerous genetic diseases associated with chromosome 3.
Function:
Alpha-1,3-xylosyltransferase, which elongates the O-linked xylose-glucose disaccharide attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of the second xylose.
Subunit:
Monomer. Homodimer. Dimer formation may be essential for the retention in endoplasmic reticulum.
Subcellular Location:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Similarity:
Belongs to the glycosyltransferase 8 family.
Database links:
Entrez Gene: 152002 Human
SwissProt: Q8NBI6 Human
SwissProt: Q3U4G3 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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