background:
[FUNCTION] Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation. [COFACTOR] Divalent metal cations. Manganese or cobalt.
Subcellular Location:
Membrane.
Similarity:
Belongs to the TIKI family.
Database links:
Entrez Gene: 129293 Human
SwissProt: Q86V40 Human
Unigene: 469134 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|