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Rabbit Anti-C2orf24/FITC Conjugated antibody
background:
The second largest human chromosome, 2 consists of 237 million bases encoding over 1,400 genes and making up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene. The lipid metabolic disorder sitosterolemia is associated with ABCG5 and ABCG8. An extremely rare recessive genetic disorder, Alstr鰉 syndrome is due to mutations in the ALMS1 gene. Interestingly, chromosome 2 contains what appears to be a vestigial second centromere and vestigial telomeres which gives credence to the hypothesis that human chromosome 2 is the result of an ancient fusion of two ancestral chromosomes seen in modern form today in apes. The C2orf24 gene product has been provisionally designated C2orf24 pending further characterization.
Subcellular Location:
Membrane; Single-pass membrane protein (Potential).
Similarity:
Belongs to the CNPPD1 family.
Database links:
Entrez Gene: 27013 Human
Entrez Gene: 69171 Mouse
Entrez Gene: 316530 Rat
SwissProt: Q5E9J2 Cow
SwissProt: Q9BV87 Human
SwissProt: Q8K158 Mouse
SwissProt: Q6P7B2 Rat
Unigene: 4973 Human
Unigene: 28193 Mouse
Unigene: 101111 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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