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Rabbit Anti-C1orf80/FITC Conjugated antibody
background:
AIDA, also known as C1orf80, is a 306 amino acid protein that belongs to the axin interactor family. Expressed in a variety of tissues, including skeletal muscle and heart, AIDA functions as a ventralizing factor during embryogenesis, disrupting Axin homodimerization and inhibiting Axin-mediated JNK activation. Axin, a scaffold protein, is important for both JNK signaling and the canonical Wnt pathway, two processes that play an essential role in embryonic dorsoventral patterning. Disruption of Axin by AIDA results in the negative regulation of JNK and Wnt signaling, thereby affecting embryonic developmental events. Three isoforms of AIDA exist due to alternative splicing events.
Function:
Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity).
Subunit:
Interacts with AXIN1 (By similarity).
Tissue Specificity:
Widely expressed in adult tissues, with highest expression in the heart and skeletal muscle.
Similarity:
Belongs to the AIDA family.
Database links:
Entrez Gene: 64853 Human
Omim: 612375 Human
SwissProt: Q96BJ3 Human
Unigene: 156625 Human
Unigene: 534965 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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