Home
>
Product
>
Antibody
>
Rabbit Anti-FCER1A/FITC Conjugated antibody
background:
The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Aug 2011]
Function:
Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein.
Similarity:
Contains 2 Ig-like (immunoglobulin-like) domains.
Database links:
Entrez Gene: 2205 Human
Omim: 147140 Human
SwissProt: P12319 Human
Unigene: 897 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|