background:
Enkurin is a 256 amino acid adapter protein that brings signal transduction proteins and transient receptor potential canonical (TRPC) cation channels into contact. Localizing to the acrosomal crescent and flagellar principal piece of sperm, Enkurin contains one IQ domain which it uses to bind CaM (calmodulin). Enkurin is highly expressed in testis and vomeronasal organ, but is also found at lower levels in brain, ovary, heart and lung. The gene encoding Enkurin maps to human chromosome 10, which contains over 800 genes and 135 million nucleotides. PTEN is an important tumor suppressor gene located on chromosome 10 and, when defective, causes a genetic predisposition to cancer development known as Cowden syndrome. Other chromosome 10 associated disorders include Cockayne syndrome, tetrahydrobiopterin deficiency and trisomy 10.
Function:
Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel (By similarity).
Subunit:
Binds calmodulin via its IQ domain. Interacts with TRPC1, TRPC2, TRPC5, but not TRPC3 (By similarity).
Subcellular Location:
Cell projection, cilium, flagellum. Note=Sperm acrosomal crescent and flagellar principal piece.
Similarity:
Contains 1 IQ domain.
Database links:
Entrez Gene: 219670 Human
Entrez Gene: 71233 Mouse
GenBank: NM_145010 Human
Omim: 611025 Human
SwissProt: Q8TC29 Human
SwissProt: Q6SP97 Mouse
Unigene: 534486 Human
Unigene: 27658 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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