background:
RNA polymerase II (Pol II) is an enzyme that is composed of twelve subunits and is responsible for the transcription of protein-coding genes. Transcription initiation requires Pol II-mediated recruitment of transcription machinery to a target promoter, thereby allowing transcription to begin. The integrator complex is a multi-protein complex that associates with the SLCterminal domain of Pol II and is involved in small nuclear RNA (snRNA) transcription and 3’-end processing. INTS3 (integrator complex subunit 3), also known as INT3 or SOSS-A, is a 1,043 amino acid nuclear protein and is a subunit of the Integrator complex, which associates with the SLCterminal domain of RNA polymerase II large subunit and mediates 3-prime end processing of small nuclear RNAs U1 and U2. Expressed in the nucleus, INTS3 exists as four alternatively spliced isoforms and is encoded by a gene located on human chromosome 1q21.3.
Subunit:
Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12. Component of the SOSS complex, composed of SOSS-B (SOSS-B1/OSFC2B or SOSS-B2/OSFC2A), SOSS-A/INTS3 and SOSS-C/C9orf80. SOSS complexes containing SOSS-B1/OSFC2B are more abundant than complexes containing SOSS-B2/OSFC2A. Interacts with SOSS-B1/OSFC2B, SOSS-B2/OSFC2A and SOSS-C/C9orf80; the interaction is direct. Interacts with NBN/NBS1.
Subcellular Location:
Nucleus. Note=Localizes to nuclear foci following DNA damage.
Similarity:
Belongs to the Integrator subunit 3 family.
Database links:
Entrez Gene: 65123 Human
Entrez Gene: 229543 Mouse
Omim: 611347 Human
SwissProt: Q68E01 Human
SwissProt: Q7TPD0 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|
